Influenza virus antigens in human leukocytes after oral administration of live tissue culture influenza A monovaccine.
Identifieur interne : 002A40 ( Main/Exploration ); précédent : 002A39; suivant : 002A41Influenza virus antigens in human leukocytes after oral administration of live tissue culture influenza A monovaccine.
Auteurs : G E Rukavishnikova ; A K AlekseevaSource :
- Acta virologica [ 0001-723X ] ; 1977.
Descripteurs français
- KwdFr :
- Administration par voie orale, Animaux, Antigènes viraux (analyse), Cytoplasme (immunologie), Humains, Injections veineuses, Leucocytes (immunologie), Poulets, Recombinaison génétique, Souris, Technique d'immunofluorescence, Techniques de culture, Test des rosettes, Vaccins antigrippaux (administration et posologie), Virus de la grippe A (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- analyse : Antigènes viraux.
- immunologie : Cytoplasme, Leucocytes, Virus de la grippe A.
- Administration par voie orale, Animaux, Humains, Injections veineuses, Poulets, Recombinaison génétique, Souris, Technique d'immunofluorescence, Techniques de culture, Test des rosettes.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Antigens, Viral (analysis), Chickens, Culture Techniques, Cytoplasm (immunology), Fluorescent Antibody Technique, Humans, Influenza A virus (immunology), Influenza Vaccines (administration & dosage), Injections, Intravenous, Leukocytes (immunology), Mice, Recombination, Genetic, Rosette Formation.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , analysis : Antigens, Viral.
- immunology : Cytoplasm, Influenza A virus, Leukocytes.
- Administration, Oral, Animals, Chickens, Culture Techniques, Fluorescent Antibody Technique, Humans, Injections, Intravenous, Mice, Recombination, Genetic, Rosette Formation.
Abstract
Influenza A virus antigens were detected in leukocytes by immunofluorescence. After intravenous inoculation of the A/Moscow/16/65 (H2N2) vaccine strain to chickens, cytoplasmic antigens of the virus were observed in mononuclear leukocytes from 24 to 72 hours post inoculation (p.i.). The course of antigen detectability was similar after two repeated inoculations of the virus. After oral vaccination of human volunteers with a live tissue culture influenza A monovaccine from the X-47 (H3N2) recombinant viral antigens were also found in mononuclears; the maximal number of antigen-positive cells was observed at 24 hours p.i. The method of membrane immunofluorescence proved to be the most sensitive for antigen detection; it revealed a considerable decrease in the number of antigen-positive cells after repeated administration of the virus to volunteers. This fact may possibly reflect the development of antiviral resistance in the process of vaccination.
PubMed: 22233
Affiliations:
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Le document en format XML
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After intravenous inoculation of the A/Moscow/16/65 (H2N2) vaccine strain to chickens, cytoplasmic antigens of the virus were observed in mononuclear leukocytes from 24 to 72 hours post inoculation (p.i.). The course of antigen detectability was similar after two repeated inoculations of the virus. After oral vaccination of human volunteers with a live tissue culture influenza A monovaccine from the X-47 (H3N2) recombinant viral antigens were also found in mononuclears; the maximal number of antigen-positive cells was observed at 24 hours p.i. The method of membrane immunofluorescence proved to be the most sensitive for antigen detection; it revealed a considerable decrease in the number of antigen-positive cells after repeated administration of the virus to volunteers. This fact may possibly reflect the development of antiviral resistance in the process of vaccination.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Alekseeva, A K" sort="Alekseeva, A K" uniqKey="Alekseeva A" first="A K" last="Alekseeva">A K Alekseeva</name><name sortKey="Rukavishnikova, G E" sort="Rukavishnikova, G E" uniqKey="Rukavishnikova G" first="G E" last="Rukavishnikova">G E Rukavishnikova</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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